§Úªº³Ì·R ³]¬°­º­¶ Ápµ¸§Ú­Ì
¡»¸Ü²á­Ñ¼Ö³¡ | ¡»¤å³¹·j¯Á | ¡»¤Í¯¸³sµ² | ¡»¯d¨¥&µo°Ý°Ï | ¡»³¯Â@¶hÂå®v²¤¶ | ¡»¼v­µe¾Ç­b-¥Á²³ª© | ¡»¼v­µe¾Ç­b-ÂåÅ@ª© | ¡»Àù¯gÃĪ«ªvÀøÁ¿®y
>­º­¶ -> ¨ÅÀù¦³±s¦u¥Í©R¦V«e¨« -> HER2¶§©Ê

TOP

§ÜÊ^药ª«Î`¦XÊ^¥ý驱ªÌ-TDM1 trastuzumab emtansine
[ µo¥¬ªÌ:³¯Â@¶h | ®É¶¡:2020-03-18 09:59:30 | §@ªÌ:¥x湾Àù¯g陈骏 | ¨Ó·½: | ÂsÄý:506¦¸ ]

ºI¦Ü2020¦~2¤ë¡A¥þ²y¤w经¦³7´Ú§ÜÊ^药ª«Î`¦XÊ^(antibody-drug conjugates, ADCs)药ª«¤W¥«¡A¦ÓT-DM1(trastuzumab emtansine)¬O²Ä¤@个¦b®Ö­ã¥Î¤_HER-2阳©Ê¨ÅÀùªv疗ªºADC药ª«¡A开创¤F¨ÅÀù¤¤ADC药ª«ªv疗ªº¥ý驱¡C

 

 

T-DM1¬O¥Ñtrastuzumab ¡BüL®Äªº¤Æ疗药剂DM1¡]¬üµn¤ì¥Íª«¡^³q过²¸îÅ连±µÊ^°¸联¦Ó¦¨ªº§ÜÊ^药ª«Î`¦XÊ^¡A¨C个T-DM1¤¤¬O¥Ñtrastuzumab 结¦X¥­§¡3.5DM1¤À¤l¡C©Ò¥HT-DM1¨ã¦³trastuzumab ©MDM1ªº双­«§@¥ÎÉó¨î¡A¨ä§@¥Î过µ{¥]¬Atrastuzumab³¡¤ÀÉO肿½F§Ü­ì结¦X¡BT-DM1§Ü­ìÎ`¦Xª«³q过¨üÊ^¤¶导ªº内§]¾½§@¥Î进¤JHER-2阳©Ê¨ÅÀù细­M¡B细­M内·»酶Ê^¤À¸Ñ¦}释©ñ¤Æ疗药剂DM1¡B¦ÓDM1¦p¦P¨ä¥L¤Æ疗药剂¤@ý©会§í¨î肿½F细­M·LºÞ»E¦X¡A©Ò¥H³Ì终¥i¥H¦³®Ä发挥§Ü肿½F§@¥Î¡CÏúÏú®Ä应颇类¦ü«n¬ü¬w¤gµÛ¥H¬r½bµì¥Ö肤¤Wªº§t¦³³Â药©Ê质ªºª«质¡AÒ\©Ù¦b¤}½b¤W¡AµM¦Z猎®·动ª«¡A³Q®g¨ìªº动ª«¡A³Â药会顺þÓ¥Ö肤伤¤f渗¤J动ª«¦å¤¤¡A导­P动ª«©ü³Ö¤£动¡C

 

 

ÉO¦¹¦P时¡AT-DM1¤¤ªºtrastuzumab ¤£仅发挥¤F类¦ü¨µ¤|飞弹¯ëªº¹v¦V©w¦ìªº§@¥Î¡Atrastuzumab还诱发¤FADCC§@¥Î¦Ó杀灭肿½F细­M¡Aªý断¤FHER-2阳©ÊÀù细­M¼W´Þ«H号¡C©Ò谓ªºADCC (antibody-dependent cell-mediated cytotoxicity¡A缩写ADCC¡^§@¥Î¡A¤¤¤å¦W称为§ÜÊ^¨Ì赖ªº细­M¤¶导¡]´C¤¶¡^ªº细­M¬r杀©Ê§@¥Î¡A这¬O¤@Ïú细­M¤¶导ªº§K¬Ì¨¾±sÉó¨î¡A¦b¹v细­M½¤ªí­±§Ü­ì结¦X¤F¯SÉݩʪº§ÜÊ^ªº±¡úG¤U¡A进¦Ó¿E¬¡§K¬Ì¨t统ªº®Ä应细­Mµõ¸Ñ¹v细­Mªº§@¥Î¡CT-DM1¤¤ªºtrastuzumab§@为经¨åªº¨ÅÀù§ÜHER2药ª«¡A¯àû{发挥°ª«×¯SÉݪº¹v¦V结¦X§@¥Î¡A¦¹¥~¨ä§@为³J¥Õ质¤j¤À¤l¥»¨­¤]¨ã¦³¬Û对较¦nªº稳©w©Ê¡A¦]¦¹¨C个 trastuzumab¯àû{结¦X¥­§¡3.5DM1¤À¤l¡A¨Ï³Ì¦Z释©ñ¥Xªº¬r¯À¤p¤À¤lDM1ªº浓«×´£°ª¡C¨ä¦¸¡ADM1§@为Àù细­Mªº·LºÞ³J¥Õ§í¨î药ª«¡A¯àû{üL®Äªº杀伤肿½F细­M¡AÊ^¥~细­M¬r©Ê测©w结ªG显¥Ü¡ADM1ªº§ÜÀù®Äɲ¬Oµµ§ü¾J©M长¬Kªá¥Íª«þé类药ª«ªº20¡ã200­¿¡C¦Ó°¸联trastuzumab ©MDM1ªº²¸îÅ连±µÊ^¯àû{«Ü¦nªº«O«ùDM1ªº´k©Ê状态¡A¨Ï药ª«结ÌÛ稳©w¡A从¦ÓÁ×§K¹v¦V¥~ªº¬r©Ê¡C

 

°ò¤_T-DM1独¯Sªº§@¥ÎÉó¨î¡A¨ã¦³°ª«×©w¦ì¹v¦V¡B¥[üL§@¥ÎÉó¨î©M疗®Ä稳©wªº¯S点¡C总结¦Ó¨¥¡AT-DM1¨ã¦³¡§No One, Only One¡¨ªº¯S点¡A§@为¤@Ïú标¹v药ª«¡AúÒ¯à发挥¥X¤ñHER2标¹v药ª«§óüL疗®Ä¡B¤ñ¤Æ疗药ª«§ó¦w¥þªº双­«疗®Ä¡C

 

 

 

 

ª¾识´N¬O¤O¶q(Knowledge is Power. )
给¦Û¤v¤@个§Æ±æ(Hope is something you give yourself. )

§ÜÀù¸ô¤W §A(©p)¦}¤£©t单
欢ªï¦ÜYoutube订阅Àù¯g·s观点医学±Ð¨|频¹D ûñ§U§A赢¦b§ÜÀùªº°_¶]点

§ó¦h¬Û关«H®§请¦Ü

陈骏¶h医师ªº话²á­Ñ乐³¡ http://cancerfree.medicalmap.tw/

¥x¤¤¥«¥þ¤è¦ìÀù¯g关Êä协会ÊI¯¸ http://www.cancerinfotw.org/

¬Û关医疗ªA务«H®§: 陈骏¶h医师门诊ªA务时¬q (2019.12.01¤½§i) http://cancerfree.medicalmap.tw/bencandy.php?fid=156&aid=4162

 

 

[¤W¤@½g]§ÜÅéÃĪ«½Æ¦XÅé¥ýÅXªÌ-TDM1 trast.. [¤U¤@½g]¨S¦³¤F

 
±À¨ì Facebook!
±À¨ì Twitter!
±À¨ì Plurk!

¬ÛÃöÄæ¥Ø

³Ì·s¤å³¹

¼öªù¤å³¹

±ÀÂˤ峹

¤Í¯¸³sµ²

¤¤¥¡°·«O§½
°ê®aºô¸ôÂå°|
§ÜÀù¦³±s¦u ¥Í©R¦V«e¨« ³¯Âå®v»P§A¦A³y°·±d