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Doxoruibicin(Âå®v±`¦]¬°ÃÄ«~¥~Æ[À¸ºÙ¬°¤p¬õ²ù)¥i¯à³y¦¨¤ß¬r©Ê(cardiotoxicity)¡AÄÝ©óAnthracyclineÃþ¤ÆÀøÃÄ«~¡A·|³z¹L¤TºØ¾÷Â২§ð¤ß¦Ù²Ó­M¡A¤À§O¬O¡G

 

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(2) ¼W¥[¦Û¥Ñ°ò (free radical)¡G¤w¸g¼Æ¤£²M¦h¤ÖÃÄ«~ªº¬r©Ê»P¦Û¥Ñ°ò¦³Ãö¡AanthracyclineÃþÃÄ«~µ²ºc¤WªºÈÐquinoneÈСA·|»P®ñ¤À¤l¹q¤l¥æ´«¡C°£¦¹¤§¥~¡A¥L­Ì·|»PÈÐÅKÈЧΦ¨½Æ¦Xª«¡A¶i¤J®ñ¤ÆÁÙ­ì¤ÏÀ³Ãì¡A³o¨â­Ó¤ÏÀ³³£·|²£¥Í¹L¦hªº¦Û¥Ñ°ò¡C

 

(3) §í¨î©Ý¾ë²§ºc酶 (topoisomerase) ³y¦¨DNAÂ_Ãì¡G¥Í¤Æ¦Ñ®v¦V§Ú­Ì´§¤â¤F¡A©Ý¾ë²§ºc酶¤@ª½¬ODNAÂùªÑ¤À¤À¦X¦Xªº­«­n±À¤â¡AanthracyclineÃþÃÄ«~·|§í¨î©Ý¾ë²§ºc酶2b (beta)¡A¨ÏDNAÂùªÑÂ_Ãì¡C

 


 

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